publications / projects
Published work and ongoing projects at the intersection of biology, AI, and engineering the immune system to catch cancer earlier and deal with it better.
Siddhesh Mittra, Shane M. Harding, Susan M. Kaech
First-author review on how memory T cell subsets, especially tissue-resident memory and stem memory T cells, may contribute to cancer immunoprevention.
read →Work on CRISPR-All, a unified genetic perturbation language for designing and combining genetic programs in primary human cells, including T cell engineering contexts.
read →A tool for designing modular genetic perturbations in T cells. The editing layer of cell engineering.
How T cells recognize cancer, and how sensitivity, specificity, and cell state (including the role of noncoding RNA and lncRNAs) shape whether recognition holds or breaks down.
Research and writing on how memory T cells may shape cancer immunoprevention.
Using computational tools to reason about perturbations, receptor designs, cell states, and experimental design.